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To this end, many drugs have been repurposed, including tocilizumab, sarilumab, heparin, chloroquine, ivermectin, sarilumab, chromones ( Most of the effort has been so far devoted to the identification of medications capable to revert the worst and life-threatening complications of COVID-19, namely cytokine storm and hypercoagulation ( This crucial phase of the malady, in analogy with other viral infections and to a widely accepted pharmacological praxis, should be timely treated either with etiotropic drugs (which in COVID-19 case are still lacking) as well as with host-directed agents to manage/prevent the symptoms ( NSAIDs, Paracetamol, and COVID-19 In March 2020, ibuprofen and NSAIDs were discouraged because of the alert by Micallef et al

Antiviral RNA silencing is typically disrupted by virus-encoded RNA-silencing suppressors as a counter-defense mechanism 54,55

J Clin Endocrinol Metab 19:45, 1959