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The lysine residue in GHK-Cu is particularly vulnerable to oxidation, forming carbonyl derivatives that alter the peptide's redox activity and copper-binding affinity
In a breast cancer model, berberine inhibits tumor growth under hypoxic conditions by modulating the inflammatory cytokine network and immune cell infiltration [210, 211]

Many find adequate results at 10 mg or 12.5 mg with fewer side effects
doi: 10.1016/j.jdcr.2019.09.014