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This was supported by the evidence that the genetic removal of Mfn2 in POMC neurons results in severe obesity characterized by excessive eating and reduced energy expenditure (66)

While iodine deficiency affects the population and causes endemic consequences (55)

Methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Psychological Information Database (PsycINFO), and the World Health Organization International Clinical Trials Registry Platform for all randomized control trials, comparing LC alone or in combination with other standard treatments for the treatment of PCOS from inception till June 2021