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Recent studies demonstrated that estrogen and ER exhibit protective antioxidant effects, primarily by promoting FGF2 production, which protects Mller and other retinal cells from oxidative damage

This hormonal effect accounts for sexual characteristics changes in immune function, and the higher susceptibility of women to autoimmune diseases like SLE ( It will be crucial to distinguish the interplay of gut microbiota and the sex hormones as it can potentially unlock the mechanisms of higher susceptibility of females to SLE and also unveil novel avenues of therapeutic intervention by manipulation of the gut microbiome for controlling disease course ( 3 Probiotics and systemic lupus erythematosus Probiotics are live microorganisms significant for their role in immunomodulation in SLE patients, as they restore gut microbiota balance and enhance immune function

274 Significant evidence implicates dysregulation of the 5-HT system (including metabolism of its key precursor, tryptophan) at both ends of the BGM axis in psychopathology