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960 Preclinical studies have shown that metformin enhances chemotherapy sensitivity by disrupting the HIF-1/PKM2 pathway, inducing apoptosis, and preventing epithelialmesenchymal transition

Curcumin, a well-known polyphenol with antioxidant and anti-inflammatory properties (Perrone et al., 2019), also becomes more biologically active after microbiome metabolism (Table 2) (Di Meo et al., 2019), suggesting that a diverse microbiome plays an important role in achieving maximum effects from such compounds

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Populations were incubated for 24 hr at 25C with PI (a 10 L volume of 0.25 mg/mL solution added to the bacterial lawn on 50 mm NGM plates) prior to the described age or with concurrent exposure to 10 mM DEM (as described above) and PI