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In recent years, antioxidant-based strategies have garnered considerable attention, particularly those that target endogenous antioxidant pathways, such as the GSK-3-mediated regulation of the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) axis

Once activated, phospholipase C propagates the signal by cleaving a lipid molecule that is a component of the plasma membrane

With this in mind, it seems likely that the relative contribution of any single environmental oxidative stressor to the prevalence of autism is most likely dependent on the location or population in question

Liu et al., 2018)