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The dietary contribution to GAG sulfation has been reviewed extensively elsewhere [3]

2.2.3 Regulatory role of intestinal excretion Quantitative contribution: Using C14 tracer studies, Sorensen (1965) demonstrated that a significant portion of total body uric acid turnover (1/3) is excreted via the intestine (extrarenal elimination pathway) compared to 2/3 excreted renally (Du et al., 2024)

Z 1 is H, (C 1 -C 5 ) alkyl, or phenyl optionally substituted with one, two, or three groups of (C 1 -C5) alkyl, (C 1 -C5) alkoxy, (C 1 -C 4 ) thioalkoxy, halogen, nitro, COOR, ONHR, -O(CH 2 ) n COOR, -S(CH 2 ) n COOR, -O(CH 2 ) n CONHR, or - S(CH 2 ) n CONHR wherein n and R are as defined above
