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Effector phase Whenever the same allergen is encountered again during the effector phase, IgE bound to FcRI on the surface of mast cells and basophils cross-links, activating and degranulating them and releasing reactive mediators that cause an acute systemic allergic response (Pasha et al

(b) Histone modifications Active markers like H3K27ac signify astrocyte enhancers controlling region-specific genes (Welle et al., 2021

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The depletion of glutathione also plays a critical role in the exacerbation of mast cell activation syndrome (MCAS) and dysautonomia, including postural orthostatic tachycardia syndrome (POTS)