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CoQH2/CoQ ratio plays a key role in using the alternative oxidase (AOX) to accept electrons from CoQ and cause a reduction in the CoQH2/CoQ ratio, leading to a decrease in rearranged during transfection (RET) and ROS generation (Szibor et al., 2020)

LXR suppresses inflammatory gene expression and neutrophil migration through cis-repression and cholesterol efflux

They simply increase the methyl load that must be processed and excreted, which places additional demand on one-carbon metabolism pathways