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EP0983300B1 - Bpc peptide salts with organo-protective activity, the process for their preparation and their use in therapy - Google Patents Bpc peptide salts with organo-protective activity, the process for their preparation and their use in therapy Download PDF Info Publication number EP0983300B1 EP0983300B1 EP98929345A EP98929345A EP0983300B1 EP 0983300 B1 EP0983300 B1 EP 0983300B1 EP 98929345 A EP98929345 A EP 98929345A EP 98929345 A EP98929345 A EP 98929345A EP 0983300 B1 EP0983300 B1 EP 0983300B1 Authority EP European Patent Office Prior art keywords nabpc157 disturbances salt peptide bpc Prior art date Legal status (The legal status is an assumption and is not a legal conclusion

48,133 Mutations result in decreased enzymatic activity and/or dissociation of the TPI dimer into inactive monomers

The thiomethyl shunt involves the activity of CCBL to cleave cysteine S-conjugates, and subsequent methylation with an active form of methionine to produce thiomethyl metabolites ( 9, 21 ), meaning that APAP-SG and NAC-APAP were probably biotransformed to APAP-cysteine beforehand