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no serious adverse events, no dose-limiting toxicities detected
If you develop diarrhoea after starting B12 supplementation, it is worth considering other factors that may be contributing to your symptoms
NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease
Vegans and vegetarians: Vitamin B12 is found naturally almost exclusively in animal products, making supplementation a consideration for those on plant-based diets
