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[10] In contrast, other studies report no significant impact of NAC supplements on glutathione levels

Historically, p21 was defined as a canonical regulator of cell cycle arrest, primarily functioning as a safeguard by inhibiting Cyclin-dependent kinase (CDK) complexes and enforcing G1/S and G2/M checkpoints following DNA damage 2

The SASP is the major mediator of the paracrine effects of senescent cells and drives secondary senescence

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