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In vitro assays revealed the interaction of TNBS with GSH leading to the almost instantaneous disappearance of GSH, while the reductive metabolism of TNBS by GSSG reductase generated ROS

This review provides an overview of the GSH transporter and the status of GSH transporter-based brain targeting drug delivery systems with the intention of bringing the field to the attention of a medicinal chemist for his/her expertise in organic synthesis, ligand identification and optimization.

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