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Description
Idiosyncratic DILI (IDILI) is unpredictable, not dose-dependent, and may take weeks or months to develop
Glutathione serves as a thiol donor in this process
Briefly, GSH-depleted cells (210 6 cells/ml) treated with ASA with or without NAC were incubated with 5 M DCFDA for 30 minutes at 37C
In an AD mouse model (APP NLGF ), increased expression of NRF2 reduced inflammation and oxidative stress and improved cognition (Uruno et al., 2020)
