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Abbreviations ACAA2: Acetyl-CoA acyltransferase ACACA: Acetyl-CoA carboxylase alpha ACADL: Acyl-CoA dehydrogenase long chain AT: Adipose tissue B12: Vitamin B12 BMI: Body mass index CPT1: Carnitine palmitoyltransferase-1 CPT2: Carnitine palmitoyltransferase-2 DGAT2: Diacylglycerol O-acyltransferase 2 ECHS1: Enoyl-CoA hydratase, short chain 1 ELOVL6: Elongation of very long fatty acid elongase 6 FA: Fatty acid FAO: Fatty acid oxidation FASN: Fatty acid synthase FCCP: Carbonyl cyanide-p-tri-fluoro-methoxy-phenylhydrazone GDM: Gestational diabetes mellitus GPAT2: Glycerol-3-phosphate acyltransferase HDL: High-density lipoprotein hTERT: Human telomerase reverse transcriptase IL- 1: Interleukin-1 beta IL- 6: Interleukin-6 IL- 18: Interleukin-18 KHB: Krebs-Henseleit Buffer LIPIN1: Phosphatidate phosphatase MCD: Malonyl-CoA decarboxylase MCP- 1: Monocyte chemoattractant protein-1 OCR: Oxygen consumption rate OmWAT: Omental white adipose tissue SAM: S-adenosyl methionine ScAT: Subcutaneous adipose tissue SCD: Stearoyl-CoA desaturase ScWAT: Subcutaneous white adipose tissue T2D: Type 2 diabetes TG: Triglyceride TNF: Tumor necrosis factor- UHCW: University Hospital Coventry and Warwickshire WHO: World Health Organization References Langley-Evans SC, Pearce J, Ellis S

Glucagon Receptor A receptor that, when activated alongside GLP-1 activity, promotes thermogenesis and fat oxidation rather than producing its typical hyperglycemic effect in isolation