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10.3390/ijms23126621 22 EakinG

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64 Microbial metabolite axes: Intrahepatic signal decoding from bile acids, SCFAs to tryptophan derivatives Bile acid metabolism remodeling and intrahepatic signal regulation Gut microbes, through key enzymes they encode, such as BSH and 7-dehydroxylase, deconjugate and dehydroxylate host primary bile acids to generate secondary bile acids, thereby profoundly remodeling the composition and signaling function of the bile acid pool