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This slow exchange with thiols is an important factor for possible bioconjugation applications and was thus also monitored and quantified for the KDTA 4 , using glutathione as a competitive thiol
Acta Pharm Sin B 11(12):37403755

Newby R, Muhamed S, Alty J, Cosgrove J, Jamieson S, Smith S, et al

10.1111/cge.13184 297 ZeglamA.AbugraraA.KabukaM