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Nanase (Cox-MION), a peroxidase-mimetic nanoconjugate, directly generates lipid peroxides through enzyme-like activity while its spherical structure mechanically suppresses tumor growth, achieving ~40% volume reduction in preclinical models [108]

Published safety data comes entirely from animal studies, which show excellent tolerability with no reported serious adverse events

Emerging evidence suggests these elevated enzymatic levels are sustained through combinatorial mechanisms: enhanced biosynthesis, increased transporter activity, and reduced catabolism

It remains available for the public to see for decades after the incident