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The peptides influence extends to hormonal regulation as well

However, in contrast to healthy rats showing sustained increases in GFR and RPF during treatment with bGH and rhIGF-1, no significant effects of these measures on GFR, RPF or filtration fraction were noted in 5/6 nephrectomized rats

While mechanistically interesting, stacking three or more compounds dramatically increases complexity, cost, and potential for unexpected interactions

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