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Di Giulio AM, Gorio A, Bertelli A, et al

Endogenous carnitine production occurs predominantly via biosynthetic cascades utilizing lysine and methionine as precursor substrates

The authors of those individual studies as well as the reviewers have generally attributed the lack of performance benefits with L-carnitine to the inability to increase resting muscle carnitine concentrations

It becomes effective only when these two conditions are met: You are in a calorie deficit (eating fewer calories than you burn) You are doing regular exercise ideally cardio or strength training Think of it like this: L-carnitine is the spark plug but you still need the engine (exercise) and the fuel (proper diet) to make the car move