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The immunogenicity of LNPs is effectively ameliorated by incorporating dexamethasone as an antiinflammatory agent, ursolic acid as a VATPase agonist, budesonide as a partial replacement of cholesterol, thiodigalactoside or olitigaltin as galectin inhibitors, and using 4A3SC8 as a unique ionizable lipid limiting endosomal damage [82, 84, 184], and these strategies can be extrapolated to other inhaled nanoparticles

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Carvajal-Vidal P, Fbrega MJ, Espina M, Calpena AC, Garca ML