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128 In the context of mitochondrial diseases, genetically defective respiratory chain complexes or mitochondrial dysfunction can activate mt-ISR, which aims to enhance ATP production and antioxidant capacity, thereby attempting to restore mitochondrial homeostasis before mitophagy is activated

The rationale behind this strategy is that pyridostigmine is a reversible carbamate inhibitor of acetylcholinesterase, which at doses used to treat myasthenia gravis, will occupy and protect a substantial percentage of acetylcholinesterase from being able to bind irreversibly with soman

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[DOI] [PubMed] [Google Scholar] 365.Eden J, Thorne AM, Bodewes SB, Patrono D, Roggio D, Breuer E, et al