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Retinal complications
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The rationale is based on the peripheral manifestation of neurodegenerative pathology, specifically, the accumulation of misfolded proteins such as phosphorylated -synuclein (P-SYN) in small nerve fibers of the skin
120,121,122,123,124,125 Several regulators of T cell activation are actively modified by N-glycosylation, including the TCR, the CD4 and CD8 co-receptors, inhibitory receptors such as CTLA4, and cytokine receptors including the TGF- receptors
