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2021;45 doi: 10.1016/j.redox.2021.102056

However, the study used cells from normal tissue, limiting the relevance of EMs

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In vascular smooth muscle cells (VSMCs), NADPHox-derived ROS activate redox-sensitive signaling pathways, such as ERK-2, leading to free-heme-induced concentration-dependent migration and proliferation of VSMCs (Moraes et al., 2012)