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Bring trekking poles (they help on descents)

Simultaneously, the mechanical properties of the ECM change significantly: the shear stiffness of the human nucleus pulposus increases from 12.5 kPa in Pfirrmann grade 116.5 kPa in grade V (Walter et al., 2017), collagen fibers thicken and become disorganized (Leung et al., 2014), its aggrecan synthesis decreases while degradation increases (Wuertz et al., 2007) (Table 1)

doi: 10.1073/pnas.2016897118 204 TetzG.TetzV