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For GHK-Cu specifically: the dermapen is the better choice if you are treating anti-aging or scars at 0.5 mm and above

Additionally, traditional liposomal systems often struggle to penetrate the skin deeply, limiting their effectiveness in transdermal applications [38]

More common in hospitalized patients on glucose-only fluids

A diagnostic trial utilizing physiologic doses of vitamin B12 (1 mcg daily) and observing daily reticulocyte counts after establishing a baseline may also be performed