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Pasricha SR, Tye-Din J, Muckenthaler MU, Swinkels DW

A 1-cm midline incision was made in the skin over the dorsal surface of the skull, and the skull was exposed to allow two holes, roughly 0.5 mm in diameter, to be drilled over predetermined coordinates targeting the medial prefrontal cortex (mPFC
Janky, R., et al., Mechanisms of L-Cysteine Neurotoxicity

The other is to actively utilize the hypoxic microenvironment to design prodrugs that selectively intensify local oxidative pressure [487]
