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Because cytotoxic CD8 + T-cells are less affected by CDK4/6-inhibition, abemaciclib-treatment decreases the Treg/CD8 + ratio of intratumoral T-cells and facilitates tumor cell-killing by cytotoxic CD8 + T-cells (114)

aryl does not encompass or overlap with heteroaryl, as defined herein, regardless of the point of attachment (e.g., both quinolin-5-yl and quinolin-2-yl are heteroaryl groups)

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