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Ca 2+ -regulated extramitochondrial enzymes, such as NADPH oxidases and nitric oxide synthase (NOS) under both physiological and pathological conditions, stimulate ROS formation (Roe et al

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Other mechanisms of cross-organ -sensitization in the pelvis may also occur through shared sensory neural pahways at different prespinal, spinal and supraspinal levels (20), thus causing an impairment of sensory pathways of the bladder (17)

As discussed earlier, maintaining optimal glutathione levels is a key strategy for addressing oxidative stress in Parkinson's disease