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Acknowledgements Graphical Abstract created with BioRender.com Funding Research reported in this paper was supported by the NIH National Center for Complimentary and Integrative Health under award number R21AT010956 (BPC), funding from T32GM144303 (RS) and 5K12HD051958 (VL)

The compound has been in pre-clinical investigation for decades

Available clinical data indicate that adding cagrilintide to semaglutide does not substantially increase nausea or vomiting compared with semaglutide alone ( Management of GLP-1 induced nausea and vomiting The cornerstone of preventing nausea and vomiting with GLP-1based therapy is understanding that gastrointestinal adverse effects are primarily dose related rather than drug specific

Taken together, these results suggest that NTAPP could be responsible for activating Wnt/-catenin signaling pathway via inducing production of Wnt ligands in hDP cells
