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Regulatory agencies apply stricter benefit-risk thresholds for obesity treatments than for life-threatening conditions, and tesofensines stimulant-like cardiovascular effects did not meet that threshold despite producing 10% mean weight loss

In its May 2026 public notice, the CDSCO made a definitive legal clarification under the Drugs and Cosmetics Act, 1940: products supplied in injectable form do not qualify as cosmetics under Indian law and cannot be marketed or used as such

Di L, Kems EH, Gao N, Li SQ, Huang Y, Bourassa JL, and Huryn DM (2004) Experimental design on single-time-point high-throughput microsomal stability assay

Though an interesting aspect of the cross-link formed in this case, is that it uses a non-terminal Glu to ligate to a non-terminal Lys, which seems to be rare in the process of forming an isopeptide bond