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In chronic unpredictable mild stress-induced depression-like behavior, curcumin supplementation promotes neurocyte proliferation and inhibits neuronal apoptosis, while PGC-1 inhibitor SR18292 reverses the beneficial effects of curcumin on depressed rats [135]

It is likely that neuropathic involvement could represent a major determinant of therapeutic failure, as diabetic polyneuropathy and cardiovascular autonomic neuropathy impair nitric oxide bioavailability, endothelial responsiveness, and neural transmission within the erectile pathway