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In that study, it was also indicated that this technology allows obtaining mass spectra for biopolymers including oligonucleotides and proteins, the latter having molecular weights up to 130,000, with as yet no evidence of an upper limit (Fenn et al., 1989)

208 Cholangiocarcinoma (CCA) is a malignant tumor originating in the epithelium of the biliary tract, characterized by a high propensity for metastasis and recurrence

If not tightly controlled, the repair of ICLs and clustered bi-stranded oxidized bases via DNA excision repair will either inhibit initial steps of repair or produce persistent chromosomal breaks and consequently be lethal for the cells

ROS can promote the activation of the inflammasome, proinflammatory cytokines, and inflammatory mediators produced by keratinocytes and fibroblasts