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Pivotal canonical pathways involved in pneumococci detection in the CNS and signaling to trigger the innate immune response, namely Role of PRRs in Recognition of Bacteria and Viruses , Toll-like Receptor signaling , Inflammasome pathway , NF-kB Signaling , and TREM1 Signaling , are activated by PM, and inhibited by B12 ( Figure 2B , Additional File 3 )

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