Labial Lentigo (labial melanotic macule)
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Description
Despite recent advances in the cancer therapy that significantly extend patient survival, many individuals still undergo drug resistance, even to multiple chemotherapeutic drugs, known as multidrug resistance (MDR)
This results in an increase in PKR activity in wild-type and mutant enzymes
Heme synthesis is disturbed in MDS-RS
Nat Immunol 17(12):1459 Angelin A, Gil-de-Gmez L, Dahiya S, Jiao J, Guo L, Levine MH et al (2017) Foxp3 reprograms T cell metabolism to function in low-glucose, high-lactate environments
