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immune dysregulation (allergies, asthma, and autoimmune diseases) (Round and Mazmanian 2009

In particular, AR signaling influences the fates of citrate that uniquely characterizes normal and malignant prostatic metabolism (i.e., mitochondrial export and extracellular secretion in normal prostate, mitochondrial retention and oxidation to support oxidative phenotype of primary PCa, and extra-mitochondrial interconversion into acetyl-CoA for fatty acid synthesis and epigenetics in the advanced PCa)

Together, the above studies suggest that mitochondria, and perhaps especially membrane potential and the function of the inner mitochondrial membrane, may play important roles in multiple pathways that extend lifespan

Cholesterol and other sterols bind to several immune receptors in macrophages and T cells, and dynamic changes in cholesterol biosynthesis impact directly upon innate and adaptive immune responses with implications for health and disease