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Vitamin A serves essential functions: it supports vision as a key component of rhodopsin, regulates keratinocyte and myeloid cell differentiation, modulates gene expression by binding to nuclear receptors [retinoic acid receptor (RAR) and retinoid X receptor (RXR)], and plays roles in bone development and immune function ( Acute deficiency is rare in Western countries

In addition, excessive oxidative stress induces irreversible damage to mitochondria, diminishing organelle integrity

Sundel MH, Sampaio Moura N, Cheng K, Chatain O, Hu S, Drachenberg CB, Xie G, Raufman JP
