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MCAv begins to decrease in early midlife (Alwatban et al., 2021), aligning with the reductions in global CBF observed with aging (Chen et al., 2011)
However, its role in promoting skin elasticity, reducing inflammation, and supporting cellular regeneration may contribute to improving the overall appearance of stretch marks
10.1016/j.chemosphere.2018.03.190 80 PereraF.PhillipsD

Clock genes such as Rev-erb repress distal enhancers resulting in the repression of macrophages ( Bmal1 which controls rhythmic trafficking of inflammatory monocytes to sites of inflammation (Nguyen et al., 2013)