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In humans, the APOE4 allele has been associated with increased BBB permeability (Jackson et al., 2022)
Immunoblot of UGDH in the indicated isogenic cell lines transduced with sg UGDH and expressing or not a sgRNA-resistant UGDH cDNA
population, according to an analysis of NHANES data
Probucol, a lipid-lowering agent, also exhibits antioxidant properties that reduce intracellular oxidative stress and maintain normal cellular redox state by upregulating Nrf2 and GPX4 protein expression, thereby enhancing cardiomyocyte antioxidant capacity
