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Common effects: Injection-site reactions (mild redness, slight discomfort) most common Transient headaches (resolved without intervention) Mild fatigue in some subjects (usually early in treatment) No serious adverse events reported Laboratory changes: No significant changes in blood glucose or insulin levels No effects on liver enzymes or kidney function No changes in IGF-1 levels (confirming the absence of a GH rise) No clinically significant changes in other laboratory parameters Phase 2 trials (overweight/obese subjects): Efficacy trials in overweight and obese populations confirmed the favorable safety profile

A flowchart of the experimental design is shown in Fig

However, unnecessary supplementation offers no added benefit if your B12 levels are already normal

Once you start getting injections and your levels normalize, that crushing fatigue often lifts significantly within days to weeks