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This stage of Lyme disease is so advanced that Lyme Literate Medical Doctors (LLMDs) often recommend intravenous antibiotics, administered through a peripherally inserted central catheter (PICC line)

Adv Exp Med Biol 317:1316 Li Q, Li J, Zhang L, Wang B, Xiong L (2007) Preconditioning with hyperbaric oxygen induces tolerance against oxidative injury via increased expression of heme oxygenase-1 in primary cultured spinal cord neurons

In addition, a large number of anti-tumor drugs were reported to damage DNA, produce AP sites and promote apoptosis, and AP capture efficiently enhanced their cytotoxicity [32]

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