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Male GF mice, in comparison to conventionally colonized control animals, exhibit a significantly higher hippocampal concentration of 5-HT and its main metabolite 5-hydroxyindoleacetic acid, in contrast to immunological and neuroendocrine manifestations that occur in both genders (Clarke et al., 2013
Littman, who is also an investigator with the Howard Hughes Medical Institute
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Another study published in *Science* demonstrated that NAD+ supplementation could reduce neurodegeneration in a mouse model of Alzheimers disease, further supporting the potential neuroprotective effects of NAD+
