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The peptides hormonal relevance remains theoretical and based on its effects on upstream factors (inflammation, vascular health, gut integrity) rather than direct HPG axis stimulation
Increased Vitamin B12 levels are associated with mortality in critically ill medical patients

In preclinical models of neuropathic pain, ARA 290 demonstrated beneficial effects that include IRR-dependent prevention of the development of allodynia in a peripheral nerve transection model (15) or in an inflammatory neuritis model (16), as well as attenuation of spinal cord inflammation (15)

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