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PLoS Pathog 8, e1003097 Lamsoul, I., Erard, M

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Oxidative stresses, including 4-hydroxy-2-nonenal, nitration, and oxidation, modify posttranslational -synuclein to promote -synuclein oligomerization, which inhibits oxidative stress responses as an antioxidant

For example, cancer cells produce a high amount of ROS and therefore they have to cope with enhanced oxidative stress
