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In human cells treated with ebselen, intracellular E,Zn-SOD1 was fully oxidized, showing that ebselen efficiently promotes the formation of the SOD1 intramolecular disulphide bond (between Cys57 and Cys146)

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Introduction Autism spectrum disorder (ASD) is a behaviorally defined disorder that is estimated to affect up to 1 in 45 individuals in the United States (Zablotsky et al., 2014)

To estimate any statistically significant differences between the groups, one-way ANOVA with Bonferronis multiple comparisons were employed