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Our further investigation reveals that the upregulation of GSH biosynthesis rather than dTTP is responsible for avoiding replication stress in T315I-Bcr-Abl cells

Despite these being isolates from patients, only a few strains caused cytotoxicity, reflected in release of the cytoplasmic enzyme lactate dehydrogenase (LDH), of A-431 vulvar epithelial cells in vitro (Fig

Altering the -carbon stereochemistry (from L to D) can make peptide analogues resistant to some enzymes while still being recognisable by others

This technicality arises not from a lack of efficacy but from how Glutathione functions within the body
