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While an acute pharmacological dose of NAM can be converted by CYP2E1 to nicotinamide N-oxide, which is then excreted to the urine
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To reconcile the discrepancy between the measurements and the solubility-based model predictions, previous studies have hypothesized that surface adsorption can be a predominant mechanism for water uptake of highly viscous SOMs (e.g., as characterized by particle rebound) 14,15
Elder, S
