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When present with metals like Fe 2+ , H 2 O 2 is converted to into a highly reactive hydroxyl radical OH
doi: 10.1016/j.jmb.2021.167378 [DOI] [PubMed] [Google Scholar] 85
Likewise, multifunctional nanomedicine platforms designed to induce ferroptosis, such as DHA-loaded Fe 3+ -doped MnO 2 nanosheets, may trigger excessive ROS generation and glutathione depletion beyond the tumor boundary, potentially leading to systemic inflammation, immune dysfunction, and off-target toxicity that could compromise patient safety
Antioxidant and prooxidant systems in patients with ischemic insult
