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Finally, our patient sample consisted primarily of males, limiting generalization of the results
Their overactivation results in accumulation in inflammatory areas, where they generate ROS, activate proteases of soluble proteins, induce innate and adaptive immune responses, release neutrophil extracellular traps (NETs), mediate gene expression and cell signaling, cellular metabolism, ultimately precipitating local tissue damage (61)
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[DOI] [PubMed] [Google Scholar] 163.Wen D., Wu L., Wang M., Yang W., Wang X., Ma W., Sun W., Chen S., Xiang L., Shi Y
