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Latest metabolic screening has shown a preferred accumulation of many metabolites and overexpression of genes of glutamine synthesis (glutaminolysis) pathways (e.g., glutamate, alpha-ketoglutarate (AKG), Glutamic pyruvate transaminase (GPT2), and Glycine amidinotransferase (GATM)) in IL-4-induced M2 macrophages (Biswas 2015)

Inoue D, Suzuki T, Mitsuishi Y, Miki Y, Suzuki S et al (2012) Accumulation of p62/ SQSTM1 is associated with poor prognosis in patients with lung adenocarcinoma

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